Scientific publications

  1. Bell et al. (2016) Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep, 6:25187. Read article...
  2. Sison-Young et al. (2017) A multi-center assessment of the application of primary human hepatocytes, HepG2, HepaRG and Upcyte cells as single cell models of acute hepatotoxicity. Arch Toxicol 91(3):1385-1400. Read article...
  3. Lauschke et al. (2016) Massive rearrangements of the non-coding RNAome are a key driver of hepatocyte dedifferentiation. Hepatology 64(5):1743-1756. Read article...
  4. Lauschke et al. (2016) Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates. Chem Res Tox 29(12):1936-1955. Read article...
  5. Lauschke et al. (2016) The importance of patient-specific factors for hepatic drug response and toxicity. Int J Mol Sci, 17(10). Read article...
  6. Hendriks et al. (2016) Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Sci Rep, 6:35434. Read article...
  7. Vorrink et al. (2017) Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics. FASEB J, doi: 10.1096/fj.201601375R. [Epub ahead of print]. Read article...
  8. Bell et al. (2017) Transcriptional, functional and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells and 3D human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury.Drug Metab Disp, doi: 10.1096/fj.201601375R. [Epub ahead of print]. Read article...