Scientific publications

  1. Oliva-Vilarnau et al. A 3D Cell Culture Model Identifies Wnt/ β-Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration. Adv Sci (Weinh). 2020 Jun 23;7(15):2000248. doi: 10.1002/advs.202000248. PMID: 32775153. Read article...
  2. Hendriks et al. Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes. Clin Pharmacol Ther. 2020 Oct;108(4):844-855. doi: 10.1002/cpt.1860. PMID: 32320483. Read article...
  3. Hurrell et al. Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis. Cells. 2020 Apr 14;9(4):964. doi: 10.3390/cells9040964. PMID: 32295224. Read article...
  4. Zhou et al. Comprehensive Evaluation of Organotypic and Microphysiological Liver Models for Prediction of Drug-Induced Liver Injury. Front Pharmacol. 2019 Sep 24;10:1093. doi: 10.3389/fphar.2019.01093. PMID: 31616302. Read article...
  5. Hendriks et al. Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids. Toxicol Sci. 2019 Aug 27:kfz195. doi: 10.1093/toxsci/kfz195. PMID: 31505000. Read article...
  6. Lauschke et al. 3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications. Biotechnol J. 2019 Jul;14(7):e1800347. doi: 10.1002/biot.201800347. PMID: 30957976 Read article...
  7. Cordero-Herrera et al. AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis. Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):217-226. doi: 10.1073/pnas.1809406115. PMID: 30559212. Read article...
  8. Kozyra et al. Human hepatic 3D spheroids as a model for steatosis and insulin resistance. Sci Rep. 2018 Sep 24;8(1):14297. doi: 10.1038/s41598-018-32722-6. PMID: 30250238. Read article...
  9. Baze et al. Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells. Tissue Eng Part C Methods. 2018 Sep;24(9):534-545. doi: 10.1089/ten.TEC.2018.0134. PMID: 30101670. Read article...
  10. Ingelman-Sundberg and Lauschke. Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions. Pharmacogenomics. 2018 Sep 1;19(14):1133-1138. doi: 10.2217/pgs-2018-0096. PMID: 30041575. Read article...
  11. Parmentier et al. Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent. Toxicol Lett. 2018 Oct 1;295:187-194. doi: 10.1016/j.toxlet.2018.06.1069. PMID: 29913214. Read article...
  12. Vorrink et al. Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions. Toxicol Sci. 2018 Jun 1;163(2):655-665. doi: 10.1093/toxsci/kfy058. PMID: 29590495. Read article...
  13. Messner et al. Transcriptomic, Proteomic, and Functional Long-Term Characterization of Multicellular Three-Dimensional Human Liver Microtissues. Appl In Vitro Toxicol. 2018 Mar 1;4(1):1-12. doi: 10.1089/aivt.2017.0022. PMID: 32953943. Read article...
  14. Bell et al. Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study. Toxicol Sci. 2018 Apr 1;162(2):655-666. doi: 10.1093/toxsci/kfx289. PMID: 29329425. Read article...
  15. Vorrink et al. Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics. FASEB J. 2017 Jun;31(6):2696-2708. doi: 10.1096/fj.201601375R. PMID: 28264975. Read article...
  16. Bell et al. Transcriptional, Functional, and Mechanistic Comparisons of Stem Cell-Derived Hepatocytes, HepaRG Cells, and Three-Dimensional Human Hepatocyte Spheroids as Predictive In Vitro Systems for Drug-Induced Liver Injury. Drug Metab Dispos. 2017 Apr;45(4):419-429. doi: 10.1124/dmd.116.074369. PMID: 28137721. Read article...
  17. Lauschke et al. Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation. Hepatology. 2016 Nov;64(5):1743-1756. doi: 10.1002/hep.28780. PMID: 27532775. Read article...
  18. Hendriks et al. Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability. Sci Rep. 2016 Oct 19;6:35434. doi: 10.1038/srep35434. PMID: 27759057. Read article...
  19. Lauschke et al. The importance of patient-specific factors for hepatic drug response and toxicity. Int J Mol Sci. 2016 Oct 12;17(10):1714. doi: 10.3390/ijms17101714. PMID: 27754327. Read article...
  20. Lauschke et al. Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates. Chem Res Toxicol. 2016 Dec 19;29(12):1936-1955. doi: 10.1021/acs.chemrestox.6b00150. PMID: 27661221. Read article...
  21. Sison-Young et al. A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity. Arch Toxicol. 2017 Mar;91(3):1385-1400. doi: 10.1007/s00204-016-1745-4. PMID: 27344343. Read article...
  22. Bell et al. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease. Sci Rep. 2016 May 4;6:25187. doi: 10.1038/srep25187. PMID: 27143246. Read article...