The 3D spheroid system used by HepaPredict provides a versatile human platform for a variety of applications, including:

1) Chronic in vitro toxicity tests

2) Long-term pharmacokinetic studies, such as

a. Determination of drug clearance

b. Pharmacokinetic studies

c. Identification of enzymes responsible for drug metabolism

3) Induction and inhibition studies of drug metabolizing enzymes

4) Validation of proposed hepatic drug targets

5) Drug screening and examination of pharmacokinetics and toxicity